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PTD - 342

Test Directory -  Anti-Mullerian Hormone

Synonyms 

AMH

Clinical Indications

Anti-mullerian hormone (AMH) is a protein produced by granulosa cells of the ovaries in females and by Sertoli cells of the testes in males.

In women serum AMH concentration increases with age up until the mid-twenties, after which it begins to decline. AMH correlates well with the number of follicles in the ovary (as measured by ultrasound) in women over the age of 25. In men serum AMH concentration tends to be high in childhood, then declines through puberty to low levels in adulthood.

AMH is used in IVF to assess ovarian reserve and predict response to treatment. In paediatrics, the measurement of AMH may be useful as a marker of testicular activity in determination of phenotypic sex in patients with ambiguous genitalia. AMH may also be of use as a tumour marker in patients with ovarian granulosa cell carcinoma.

Request Form 

Combined Pathology Blood form (Yellow/Black)

Availability

Referred test: Analysed by Clinical Biochemistry, Royal infirmary, Glasgow,  if specific criteria met

Specific Criteria

Marker of ovarian reserve and prediction of ovarian response in IVF treatment. Requested by Consultant Paediatrician.

Patient Preparation

 

None required

Turnaround Time

2 weeks

Specimen

Serum

Volume

1.0 ml

Container

Yellow top (SST) tube

Causes for Rejection

Not meeting specific criteria for analysis. Unlabelled sample.

Reference Ranges

Supplied with the referral report.

Interpretation

Women with high AMH values will tend to have better response to ovarian stimulation for IVF.

Lab. Handling

Processing: Aliquot into a false bottom tube and store at 4C in separating fridge (CB39), referral rack. If there will be a >48hr delay in sending samples, separate and store at -20C.

Referral: SASOD and send or BPRO and track at -20C in separating freezer (CB40).


Version 1.0 / July 2015                                                                                                          Approved by: Consultant Biochemist