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PTD-152

Test Directory - Adverse Drug Reaction

Synonyms

Anaphylactic drug reaction, plasma tryptase.

Clinical Indications

Intravenous 'drug' administration may cause immediate hypersensitivity (anaphylactic), or histamine release (anaphylactoid) reactions. These may range from minor (flushing, urticaria) to major (bronchospasm, cardiovascular collapse). They are due to the release of histamine and other vasoactive chemicals: they can be mimicked by other conditions - underlying pathology or pharmacological effects.

Test Includes

Plasma tryptase

Request Form

Combined Pathology Blood form (Yellow/Black). Full details should include complete patient ID; date & time of reaction; surgical procedure; all drugs administered; clinical signs and outcome; previous history; any risk factors; haematology results.
The National Adverse Anaesthetic Reaction Consultancy Service (NARCOS) may be contacted on 0114 243 4343. The Medicines Control Agency should also be informed.

Availability

Referred Test: Analysed by Protein Reference Unit, Sheffield if specific criteria met.

Specific Criteria

Confirmation of anaphylactic drug reaction.

Patient Preparation  

Blood taken within 60 minutes, then 3 and 24 hours after reaction; duplicate samples should be collected for FBC.

Turnaround Time

1 month

Specimen

Blood

Volume

2 ml

Container

Pink top (EDTA) blood tube. Blood taken within 60 minutes, then 3 and 24 hours after reaction; duplicate samples should be collected for FBC.
Causes for rejection

Unlabelled sample; not meeting specific criteria for analysis. 

References ranges Provided by the referral laboratory with a full interpretive comment.
Interpretation

Provided by the referral laboratory.

Lab. Handling

Processing: Aliquot and store at 4C in separating fridge (CB39).
Referral
: TRYP and send with documentation or NOTRY and save in separating freezer (CB40) at -20C, saved frozen rack.

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Version 1.0 / April 2014                                                                                                          Approved by: Consultant Biochemist