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PTD - 159

Test Directory -  Alpha-1 antitrypsin

Clinical Indications

Evaluation of chronic obstructive airway disease, emphysema (particularly occurring between 30-40 years of age) and in neonatal and adult liver disease where low values may have diagnostic importance. Family studies.

Request Form

Combined Pathology Blood form (Yellow/Black)


On request.

Specific Criteria

None. Total alpha-1 antitrypsin measured and referred for alpha-1 antitrypsin phenotyping if level is less than 1.2 g/l. If low alpha-1 antitrypsin has been picked up as an incidental finding from electrophoresis then a comment will be added to the report asking for the requesting clinician to discuss with the patient before phenotyping is carried out. 

Samples referred to Basildon Hospital will be assumed to have met specific criteria of the referring laboratory.

Turnaround Time

Same day




2 ml


Yellow top (SST) tube or

Paediatric orange top (lithium-heparin)

Causes for Rejection

Unlabelled specimen.

Reference Ranges


Age Range

Alpha-1 AT g/L


0 to 6 months

0.9 - 2.2


6 months to 1 year

0.8 - 1.8


1 to 5 years

1.1 - 2.0


5 to 10 years

1.1 - 2.2


10 to 15 years

1.4 - 2.3


15 to 18 years

1.2 - 2.0


Over 18 years

1.1 - 2.1


Reference; Protein Reference Unit Handbook, 9th Edition 2007              

Lab. Handling

Processing: Analysed from primary tube and stored at 4C in the cold room (CB23)

Version 1.1 / July 2014                                                                                                           Approved by: Consultant Biochemist