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PTD - 163

Test Directory -  Aluminium

Clinical Indications

Aluminium toxicity arises in patients with chronic renal failure (CRF) due to two reasons. Firstly, oral aluminium is used as a phosphate binder and intestinal absorption may be enhanced in CRF. Secondly, dialysis fluid may have a high aluminium content although, more recently, this is a rare cause.

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Analysed by referral laboratory if specific criteria met.

Specific Criteria

Requested by Consultant Renal Physicians for monitoring patients with renal failure who are being treated with oral aluminium (Alu-Cap).

Patient Preparation

None required

Turnaround Time

1 month

Specimen

Plasma

Volume

2 ml

Container

Orange top 10 ml Li-Heparin tube

Collection

1. Collect blood into a plastic syringe
2. Remove and discard needle
3. Discharge blood into plastic lithium heparin (Sarstedt) tube and recap.
4. Send to laboratory as soon as possible

Causes for Rejection

Not meeting specific criteria for analysis. Aluminium is prone to contamination and must be collected using plastic consumables. Glass and gel separator tubes must be avoided.

Reference Range & Interpretation

Less than 0.4 umol/L. Levels greater than 2.2 umol/L indicate increased accumulation in a renal patient. Aluminium concentration in dialysis fluid should not exceed 1.1 umol/L.

Unit Conversion

To convert from umol/L to ug/L multiply by 26.95

Lab. Handling

Processing: Aliquot and store at 4C in separating fridge (CB39).
Referral
:  ALU and send or BPRO and save in separating freezer (CB40) at -20C, saved frozen rack.

         

 


Version 1.0 / April 2014                                                                                                           Approved by: Consultant Biochemist