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PTD - 196

Test Directory -  Anti-CCP antibodies

Synonyms

Anti-cyclic citrullinated peptide antibodies, ACCP

Clinical Indications

CCP antibodies have been shown to be highly specific for Rheumatoid Arthritis (RA) and appear early in the disease process when diagnosis is most difficult and intervention most effective. CCP antibody measurement is of value in confirming the diagnosis of RA in patients with atypical presentation, excluding a diagnosis of RA in patients where the RF is positive but the clinical features are equivocal and also as an indicator of early RA.

A high proportion of patients with established Rheumatoid Arthritis (RA) have anti-CCP antibodies and relatively few patients without RA are positive (2-5% of disease controls). Anti-CCP antibodies appear early in RA and can pre-date clinical onset by years. Most, but not all, patients are also positive for rheumatoid factor (RhF). Evidence suggests that RA should be treated as early as possible to improve long-term outcome. Management of RhF-negative patients may be altered as a result of positive anti-CCP antibodies.

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Referral test: Analysed by Immunology, Southend Hospital.

Specific Criteria

There is generally no need to repeat positive patients, no repeat testing of negative patients within 12 months.

Patient Preparation

None required

Turnaround Time

1 week

Specimen

Serum

Volume

2 ml

Container


Yellow top (SST) tube or


Paediatric brown top

Causes for Rejection

Repeat analysis of previously positive result, repeat of negative patient within 12 months.

Reference Range and Interpretation

0 - 10 U/mL

A high proportion of patients with established Rheumatoid Arthritis (RA) have anti-CCP antibodies and relatively few patients without RA are positive (2-5% of disease controls). Anti-CCP antibodies appear early in RA and can pre-date clinical onset by years. Most, but not all, patients are also positive for rheumatoid factor (RhF).

Lab. Handling

Processing: Immunology at the Hub laboratory

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Version 1.1 / Feb 2017                                                                                                          Approved by: Consultant Biochemist