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PTD - 197

Test Directory -  Catecholamines (24hr Urine)

Synonyms

Adrenaline, noradrenaline.

Clinical Indications

Investigation of suspected phaeochromocytoma.

Test Includes

Free epinephrine (adrenaline), Free norepinephrine (nor-adrenaline)

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Referred test: Analysed by Clinical Biochemistry, Broomfield Hospital.

Specific Criteria

Investigation of suspected phaeochromocytoma.

Samples referred to Basildon Hospital for Urine Catecholamine analysis from other Hospitals should be packaged in accordance with our transportation policy and will be assumed to have met the specific criteria of the referring laboratory.

Patient Preparation

Certain foods (bananas, pineapples, kiwi fruit, nuts and avocados) must be avoided prior to and during collection of urine. A patient information sheet is available.

Turnaround Time

1 week

Specimen

24 hour urine collection into acid preservative

Container

Acidified 24 hour urine container

Causes for Rejection

Non-acidified urine collection. Unlabelled sample.

Reference Range

Free epinephrine: 20 - 110 nmol/24hr
Free norepinephrine: 100 - 560 nmol/24hr 

Interpretation

 

Raised epinephrine and norepinephrine. If slightly elevated (less than 2 x
upper limit of ref. range) suggest review medication and repeat collection
ensuring foods listed above are avoided. Please note that
B-blockers may raise norepinephrine levels (usually less than 1,000 nmol/24hr).If either level greater than this then medullary phaeochromocytoma possible.

Raised norepinephrine with normal/low epinephrine. If less than 1,000
then may be stress related, but a small extra-medullary tumour cannot
be excluded. Suggest review medication and repeat collection ensuring foods listed above are avoided. Please note that
B-blockers may raise norepinephrine levels (usually less than 1,000 nmol/24hr). If level greater than 1,000 then extra-medullary tumour possible.

Raised epinephrine with normal norepinephrine. If less than 220 then
may be stress related, but a small medullary phaeochromocytoma cannot be excluded. Suggest review medication and repeat collection ensuring foods listed above are avoided. If level greater than 220 then medullary phaeochromocytoma possible.

Lab. Handling   Processing: Record the 24hr volume and pH, aliquot and store at 4C in separating fridge (CB39) in the 'UCAT rack' until they are packaged up and sent via the internal courier service to the referral laboratory.

Version 1.1 / October 2014                                                                                                      Approved by: Consultant Biochemist