return to C index

return to index page

PTD - 213

Test Directory -  Urinary Free Cortisol

Synonyms

UFC

Clinical Indications

For the investigation of possible Cushing's disease.

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Analysed by Clinical Biochemistry, Broomfield Hospital if specific criteria met.

Specific Criteria

None

Patient Preparation

None

Turnaround Time

1 week

Specimen

Urine

Volume

24 hour collection

Container

Plain 24 hour container

Causes for Rejection

Unlabelled sample. Incomplete collection. Not meeting specific criteria for analysis. 

Reference Range

Less than 280 nmol/24 hours

Interpretation

A normal result does not exclude Cushings, but makes it unlikely. Repeated measurement of urine cortisol may be required as some patients with Cushing’s syndrome may have non diagnostic urine cortisol values. Normal urine cortisol excretion on three separate occasions excludes Cushing’s syndrome.

Cortisol production and therefore urinary excretion increases during stress, for example during surgery, acute illness and following trauma. Production (and hence excretion) may be reduced in starvation and in pregnancy.

Lab. Handling

 

Processing: Record the 24hr urine volume. Aliquot into a universal container and store at 4°C in separating fridge (CB39).
Referral: UFC and send or BPRO and save in separating freezer (CB40) at
-20°C.


Version 1.1 / April 2015                                                                                                               Approved by: Consultant Biochemist