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PTD - 218

Test Directory - Ciclosporin

Synonyms

Cyclosporin, Cyclosporine A, Neoral

Clinical Indications

Ciclosporin is an immunosuppressant used after organ or bone marrow transplantation, and for some non-transplant indications (e.g. psoriasis, atopic dermatitis, rheumatoid arthritis, nephrotic syndrome and ulcerative colitis).

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

On request

Specific Criteria

Monitoring of patients on ciclosporin therapy.

Samples referred to Basildon Hospital for Ciclosporin analysis from other Hospitals should be packaged in accordance with our transportation policy and will be assumed to have met the specific criteria of the referring laboratory.

Patient Preparation

Samples should be collected before next dose (trough).

Rarely patients may have antibodies to E.Coli B-Galactosidase, such samples produce artificially high results.

Turnaround Time

Same day

Specimen

Whole blood

Volume

1 ml

Container


Pink
top (EDTA) tube

Causes for Rejection

Unlabelled sample.

Reference Range and Interpretation

 

Therapeutic range varies depending on reasons for use, type and age of transplant, and concomitant disease and medication.  Renal and liver function should also be monitored.

Indicative therapeutic range (trough sample) 200 - 400 ug/L in the month following transplantation and 100 - 150 ug/L in stable patients.
Potentially toxic levels >400 ug/L

Lab. Handling

 

Processing: Test code: CYCL. Analysed from primary tube and stored at 4C in the cold room (CB23)


Version 1.2 / February 2015                                                                                                    Approved by: Consultant Biochemist