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PTD - 221

Test Directory - DHEA-S


Dehydroepiandrosterone Sulphate

Clinical Indications

DHEA-S is useful in the diagnosis of a virilizing adrenal tumour and to monitor recurrence after surgical removal. It is of little value in the investigation of acne, idiopathic hirsuitism or infertility.
DHEA-S is the first adrenal androgen to show a significant increase at the onset of adrenarche and serum levels give an indication of the stage of development in children and may be useful in the investigation of delayed or precocious adrenarche / puberty.

Request Form

Combined Pathology Blood form (Yellow/Black)


Referred test: Analysed by Clinical Biochemistry, Southend Hospital if specific criteria met.

Specific Criteria

Diagnosis / monitoring of virilizing adrenal tumour. Investigation of delayed or precocious adrenarche / puberty.

Patient Preparation

None required.

Turnaround Time

Two weeks




1 ml


Yellow top (SST) tube

After surgery samples should be taken as soon as practicable and at least every 2 months thereafter to monitor for recurrence.

Causes for Rejection

Not meeting specific criteria for analysis. Unlabelled sample. Collected into EDTA or heparin tube.

Reference Range



DHEA-S umol/L





Less than 0.50

Less than 0.50

20 to 29 years

7.60 - 17.37

1.76 - 10.31

30 to 39 years

3.26 - 14.11

1.22 - 7.33

40 to 49 years

2.58 - 14.38

0.87 - 6.51

50 to 59 years

1.90 - 8.41

0.71 - 5.43

60 to 69 years

1.14 - 7.87

0.35 - 3.53

Over 70 years

0.76 - 4.75

0.46 - 2.44



0.27 - 5.16

Reference: Southend Clinical Biochemistry

Lab. Handling  

Processing: Aliquot and freeze at -20C in separating freezer (CB40), active frozen rack 110.
DHEA and send frozen in the transport box to the referral laboratory or NODHE and save in separating freezer (CB40) at -20C, saved frozen rack.

Version 1.1 / October 2014                                                                                                    Approved by: Consultant Biochemist