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PTD - 224

Test Directory -  Faecal Elastase

Clinical Indications

Pancreatic elastase 1 (E1), a digestive protease, is synthesised by the acinar cells of the pancreas. Levels of E1 in faeces may be used as a non-invasive method to assess exocrine pancreatic status, particularly in patients with Cystic Fibrosis.

Request Form 

Combined Pathology Blood form (Yellow/Black or Blue for GP's)

Availability

Referral Test: Analysed by Clinical Biochemistry, Kings College Hospital if specific criteria met.

Specific Criteria

Requested by Consultant Paediatrician/Gastroenterologist or if agreed with Consultant Biochemist.

Patient Preparation

The assay is highly specific for human pancreatic E1 and patients do not need to stop taking pancreatic supplements before assessment of pancreatic exocrine function.

Turnaround Time

One week

Specimen

Random faecal sample.
Please note that if faecal calprotectin is also requested a separate sample is required.

Volume

500 mg

Container

Blue Capped Universal

Causes for Rejection

Not meeting specific criteria for analysis. 

Reference Range

Severe exocrine pancreatic insufficiency: < 100 ug/g faeces

Moderate exocrine pancreatic insufficiency: 100 - 200 ug/g faeces

Normal levels: > 200 ug/g faeces.

Lab. Handling

Processing: Label with a red sticker and store at 4C in the separating fridge, FELA box.
Referral:
FELA and send or NOELA and save in separating freezer (CB40) at -20C., saved universals rack.

     

Version 1.0 / May 2014                                                                                                           Approved by: Consultant Biochemist