PTD - 11

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Test Directory -  Fibrinogen

Synonyms

Clauss Fibrinogen, Fib

Clinical Indications

.As part of an investigation of a possible bleeding disorder or thrombotic episode, particularly to evaluate the level and function of fibrinogen

Request Form 

Combined Pathology Blood form (Yellow/Black or Blue for GP's)

Availability

On Request

Specific Criteria

  DO NOT use heparinised syringes / lines for collecting coagulation screens. Patient should be bled with minimal stasis, and samples received in lab within 2 hours of collection.

Turnaround Time

2 hours

Specimen

 Citrated whole blood

Volume

 3ml

Container

  1 x Blue capped vacutainer tubes

Collection

  Samples must be received by lab within 2 hours of collection. Avoid prolonged stasis during venepuncture

Lab. Handling

Samples must be received within 2 hours of collection.

Causes for Rejection

Inadequately labelled, unlabelled, haemolysed, under-filled, clotted  or lipaemic samples.

Limitations

  Activated sample, sample haemolysis or lipaemia..

Reference Range

  Fibrinogen: 2.0 to 4.5 g/L.

Interpretation

Fibrinogen is an acute phase reactant, meaning that fibrinogen concentrations may rise sharply in any condition that causes inflammation or tissue damage. Elevated concentrations of fibrinogen are not specific.
Reduced concentrations of fibrinogen may impair the body's ability to form a stable blood clot. Chronically low levels may be related to decreased production due to an inherited condition such as afibrinogenemia (no production), or to an acquired condition such as liver disease or malnutrition that leads to hypofibrinogenemia (low levels). Acutely low levels are often related to consumption of fibrinogen, such as may be seen with disseminated intravascular coagulation (DIC) and some cancers. Reduced fibrinogen levels may also be seen, sometimes, following large volume blood transfusions (as stored blood loses fibrinogen).

Version 1.0 / January 2012