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PTD - 242

Test Directory - Glycolipid Antibodies

Synonyms

Ganglioside antibodies

Clinical Indications

Investigation of patients with peripheral neuropathies (e.g. Guillain-Barré, Miller-Fisher syndromes) that may be associated with glycolipid autoantibodies

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Analysed by Neuroimmunology, Queens Square, London if specific criteria met.

Specific Criteria

Requested by Consultant Neurologist or agreed with Consultant Biochemist.

Patient Preparation

None required.

Turnaround Time

1 month

Specimen

Serum

Volume

1 ml

Container


Yellow top (SST) tube

Causes for Rejection

Unlabelled sample; insufficient clinical information.

Interpretation

Samples are screened by ELISA for IgG and IgM antibodies against gangliosides GM1, GD1a, GT1b, GQ1b.  Positive screens are titrated to measure specific levels.

Glycolipid (ganglioside) antibodies are associated with neuropathy. GD1a and GD1b antibodies in particular are associated with Guillain-Barre syndrome. GM1 antibodies are often present in multifocal motor neuropathy (MMN), Guillain-Barré syndrome (GBS), proximal lower motor neurone disease and rarely in amyotrophic lateral sclerosis (ALS).  IgG antibodies to ganglioside GQ1b are associated with Miller-Fisher syndrome and specifically those with opthalmoplegia. IgM antibodies to GQ1b are seen in some chronic ataxia neuropathies which share some common clinical features with the Miller-Fisher syndrome

Lab. Handling

Processing: Aliquot (MPA) and store at 4°C in separating fridge (CB39). Referral:  GLYAB and send or BPRO and save at -20°C in separating freezer (CB40).


Version 1.0 / May 2014                                                                                                           Approved by: Consultant Biochemist