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PTD - 268

Test Directory -  Urine Myoglobin

Synonyms

Clinical Indications

Any disease which causes rapid destruction of striated muscle (rhabdomyolysis) results in release of myoglobin into the circulation. Myoglobin has a low molecular weight and is rapidly filtered by the glomerulus. Urine myoglobin is not contributory to rhabdomyolysis diagnosis or prognosis and is not available. 

However, if required, the presence of myoglobin in urine may be detected using the 'blood' test on urine reagent sticks. Both myoglobin and haemoglobin possess peroxidase activity which gives a positive result. It is not necessary to further distinguish the cause of a positive reagent stick test since there are other biochemical features which give strong clues to the diagnosis.

Serum parameter

Myoglobinuria

Haemoglobinuria

Creatinine Kinase

Very High

Normal

Visible haemolysis

Absent

Present

Calcium

Low

Normal

Urate

Very High

Normal

Creatinine

High

Normal

Patient Preparation

None required.

Request Form 

Combined Pathology Blood form (Yellow/Black or Blue for GP's)

Availability

Should be performed on urinalysis machines situated on most wards within Basildon Hospital or alternatively it is available on request from the laboratory.

Specific Criteria

None

Turnaround Time

Same day

Specimen

Urine

Volume

5 ml

Container

White Capped Universal

Causes for Rejection

Unlabelled sample, sample in boric acid preservative.

Interpretation

Serum CK is the primary laboratory test used in investigation of rhabdomyolysis.

Lab Handling

 

UMYO and analysis is performed on the laboratory urinalysis machine. Record results on the 'miscellaneous test worksheet' before entering into the computer system.

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Version 1.0 / July 2014                                                                                                           Approved by: Consultant Biochemist