For the investigation of
14-3-3 is a normal neuronal
protein and is released into the CSF in response to a
variety of neuronal insults. It is a non-specific finding
and 14-3-3 analysis cannot be used as a screening test for
sporadic CJD. Other illnesses, which can give a positive
14-3-3 test, include:
Herpes simplex encephalitis
and other viral encephalitides.
Recent cerebral infarction
Hypoxic brain damage.
However, it is usually a
straightforward clinical matter to exclude the other
possible illnesses which may give rise to an elevated 14-3-3
level. Therefore, in an appropriate clinical context, a
positive test is strongly supportive of a diagnosis of
sporadic CJD and a negative test is unusual.
CSF S100 is analysed in addition to CSF
14-3-3 on all specimens.