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PTD-286

Test Directory - S-100 Protein

Synonyms

S100B

Clinical Indications

S-100, an acidic calcium-binding protein, is present within cells of neuroendocrine origin. Recent studies suggest S-100 has particular utility in staging of malignant melanoma, in establishing prognosis, in evaluating treatment success and in predicting relapse. Circulating S-100 levels very sensitively detect metastatic growth of malignant melanoma, particularly in stage IV disease.

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Referral test: Analysed by Biochemistry, National Hospital if specific criteria met.

Specific Criteria

Assessment and monitoring of patients with malignant melanoma.

Turnaround Time

2 weeks

Specimen

Serum

Volume

2 ml

Container

Red (plain) tube.

Yellow top (SST) tubes must not be used.

Causes for Rejection

Not meeting specific criteria for analysis.

Interpretation

It has been shown that S-100 rises 3 months before clinical signs of recurrence. A S100 level of <0.2 ug/L is a reassuring negative result.

Lab. Handling

Processing: Aliquot (MPA) and store at 4C in separating fridge (CB39), referral rack.
Referral
:  S100 and send or BPRO and track at -20C in separating freezer (CB40).


Version 1.0 / July 2014                                                                                                           Approved by: Consultant Biochemist