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PTD - 290

Test Directory -  Sirolimus


Rapamycin, Rapamune

Clinical Indications

Sirolimus is an immunosuppressive drug licensed for use in renal transplantation.

Request Form 

Combined Pathology Blood form (Yellow/Black or Blue for GP's)


Referred test: Analysed by the IMS Laboratory, Harefield Hospital.

Specific Criteria

Trough sample required: 2 - 4 hours before next dose

Patient Preparation

Samples should be collected before next dose (trough)

Turnaround Time

48 hours


Whole Blood


2 mls minimum


Pink/purple top (EDTA) tube


For paediatrics a red top (EDTA) tube is required.

Causes for Rejection

Unlabelled sample

Reference Range

Therapeutic range varies depending on reasons for use, type of transplant and concomitant disease and medication. See

Lab. Handling

Processing: Store the whole blood EDTA at 4C in the separating fridge (CB39). Referral: SIRO and send.

Version 1.0 / July 2014                                                                                                            Approved by: Consultant Biochemist