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PTD - 296

Test Directory - Tacrolimus (FK506)


Prograf, Astellas

Clinical Indications

Tacrolimus is an immunosuppressant used after organ transplantation and for some autoimmune diseases.

Request Form

Combined Pathology Blood form (Yellow/Black)


Referred test: Analysed by the IMS Laboratory, Harefield Hospital.

Specific Criteria

Monitoring of patients on tacrolimus therapy

Patient Preparation

Samples should be collected before next dose (trough)

Turnaround Time

48 hours


Whole blood


1 ml


Pink/purple top (EDTA) tube


For paediatrics a red top (EDTA) tube is required.

Causes for Rejection

Unlabelled sample.

Reference Range

Therapeutic range varies depending on reasons for use, type of transplant and concomitant disease and medication. 

Indicative target levels (trough sample) are 15 ug/L following kidney transplantation when used with steroids and mycophenolic acid, and 5 - 10 ug/L in stable patients.

Lab. Handling

Processing: Store the whole blood EDTA at 4C in the separating fridge (CB39). Referral: FK506 and send.

Version 1.0 / July 2014                                                                                                            Approved by: Consultant Biochemist