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PTD - 313

Test Directory - Urinary Steroid Profile

Clinical Indications

Urinary steroid profiling  provides a composite picture of adrenal function. Oestrogen and aldosterone metabolites are not detected under normal circumstances. Steroid metabolism in newborn infants is markedly different from that in children and adults. In the newborn infant a urinary steroid profile avoids difficulties in interpreting results derived by other techniques which may be subject to interference from unusual steroids present at this time of life.

Request Form

Combined Pathology Blood form (Yellow/Black)

Availability

Referred test: Analysed by the Clinical Biochemistry Department, UCL Hospital, London, if specific criteria met.

Specific Criteria

Requested by Consultant Paediatrician / Endocrinologist in the investigation and diagnosis of disorders of adrenal function such as male pseudo-hermaphroditism, steroid-producing tumours, steroid sulphatase deficiency, congenital adrenal hypoplasia, premature adrenarche / precocious puberty.

Patient Preparation

Neonatal samples must be 3 days post natal.

Turnaround Time

2 weeks

Specimen

Urine

Volume

Minimum 5 ml.

Container

White Capped Universal

Samples should be transported to laboratory immediately.

Causes for Rejection

Unlabelled sample.
Not meeting specific criteria for analysis. 
Delay in sample reaching laboratory.

Reference Ranges

Appropriate reference data and an interpretation of results based on relevant biochemical and clinical information will be reported.

Lab. Handling

Processing: Freeze the primary tube at -20C in the separating freezer (CB40)
Referral: SASOD and send or BPRO and save in separating freezer (CB40) at -20C, saved frozen rack.

 

 Version 1.0 / August 2014                                                                                                      Approved by: Consultant Biochemist